Director of Portfolio and Program Management for Cystic Fibrosis

Vertex Pharmaceuticals Incorporated
paid time off, 401(k)
United States, Massachusetts, Boston
50 Northern Avenue (Show on map)
Sep 29, 2025
Job Description General Summary: The Director of Portfolio and Program Management (PPM) for Cystic Fibrosis (CF) plays a critical leadership role within the COO organization at Vertex. This individual will drive the strategic execution of CF assets from development through commercialization. The ideal candidate brings deep experience in early- and late-stage clinical development and commercial launch planning. By partnering with program leads and cross-functional teams, the Director will ensure alignment, accountability, and delivery of program objectives that support Vertex's mission to transform the lives of people with serious diseases. Key Duties and Responsibilities: Partner with Program Team Leads to define cross-functional strategies and decision-making frameworks that align with program goals. Lead the development and execution of integrated program plans, identifying critical path activities, interdependencies, and potential bottlenecks. Facilitate high-impact meetings, ensuring clear communication, stakeholder alignment, and timely follow-through on decisions and action items. Translate complex scientific and business topics into compelling narratives and presentations for internal and external stakeholders. Collaborate across clinical, regulatory, manufacturing, commercial, and market access functions to ensure cohesive program execution. Guide the development of asset-level assumptions for long-range planning and annual budgeting. Proactively identify and mitigate program risks, escalating issues as needed to maintain momentum and alignment. Monitor and manage resource allocation, identifying synergies and resolving constraints across programs. Establish and reinforce team operating norms to drive high performance and continuous improvement. Mentor and develop junior team members, fostering growth in program management capabilities. Provide strategic and operational leadership for programs in late-stage clinical development, ensuring readiness for regulatory submission and approval. Partner with commercial and launch readiness teams to align development timelines with go-to-market strategies and ensure successful product launches. Knowledge and Skills: Deep expertise in project and portfolio management principles, tools, and methodologies. Proven leadership in managing complex, cross-functional drug development programs, including early- and late-stage clinical trials and commercial launch preparation. Strong business acumen with the ability to assess program scenarios across financial, timeline, and resource dimensions. Excellent communication and storytelling skills, with the ability to influence at all levels of the organization. Comprehensive understanding of the pharmaceutical development lifecycle, from discovery through commercialization. Highly organized with the ability to manage multiple priorities in a dynamic environment. Collaborative mindset with a track record of building strong partnerships across functions. Education and Experience: Bachelor's degree in Life Sciences or a related field required; advanced degree preferred. Typically requires 10+ years of experience managing cross-functional drug development teams, with demonstrated success in early- and late-stage clinical development and commercial launch execution. #LI-DB1 #LI-HYBRID Pay Range: $242,200 - $363,300 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com