Postdoctoral Fellow - Therapeutic Senescence & Tumor Immunology Laboratory of Paul Romesser, MD

The people of Memorial Sloan Kettering Cancer Center (MSK) are united by a singular mission: ending cancer for life. Our specialized care teams provide personalized, compassionate, expert care to patients of all ages. Informed by basic research done at our Sloan Kettering Institute, scientists across MSK collaborate to conduct innovative translational and clinical research that is driving a revolution in our understanding of cancer as a disease and improving the ability to prevent, diagnose, and treat it. MSK is dedicated to training the next generation of scientists and clinicians, who go on to pursue our mission at MSK and around the globe.

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Exciting Opportunity at MSK: The Romesser Lab is looking for a Postdoctoral Fellow to join our team studying therapy induced senescence and tumor immunology.

Role Overview

Dr. Paul Romesser's laboratory is recruiting a bold and innovative Postdoctoral Fellow to turn cellular senescence into a weaponized immunologic state against cancer. Rooted in rectal cancer-but engineered to translate across immunerefractory tumors-our program fuses immunocompetent mouse models, patientderived organoids, singlecell / spatial multiomics, and CRISPRbased functional genomics. You will drive NIH and foundationfunded projects that dissect the senescence-immune interface and fasttrack novel combination therapies toward firstinhuman trials, all within MSK's collaborative, technologyrich ecosystem.

Key Requirements:

PhD or MD/PhDin Cancer Biology, Immunology, Molecular Biology, or a related discipline
• Hands on expertise in at least one of the following:
  • Immunocompetent mouse tumor models
  • Patientderived organoid culture and manipulation
  • Flow cytometry or advanced immune-profiling platforms
  • Singlecell or spatial omics
• Computational proficiency-familiarity with R/Python for analysis of bulk, singlecell, or spatialomics data (or a strong willingness to learn).
• Strong publication recordthat highlights independent thinking and problemsolving.
• Excellent communication skills(written and oral) and a track record of productive collaboration within interdisciplinary teams.

Core Skills:

• Experimental Design & Troubleshooting: Ability to conceptualize, execute, and optimize complex in vivo (mouse) and ex vivo (organoid) studies, including CRISPR perturbations and multiplex assays.
• SingleCell & Spatial Multiomics: Competence in generating and/or analyzing scRNAseq and spatial transcriptomics data; comfortable using pipelines such as Seurat, Scanpy, or equivalent.
• Data Analysis & Visualization: Fluency in R/Python for statistics, data integration, and productionquality figures that clearly communicate findings to diverse audiences.
• Immunological Assays: Proficiency with flow cytometry, ELISA/LEGENDplex, functional Tcell or myeloid assays, and lymphoid and myeloid co-culture assays for dissecting tumor-immune interactions.
• Scientific Communication & Leadership: Strong track record of manuscript preparation, conference presentations, and collaborative project management; ability to mentor junior trainees and foster an inclusive lab culture.

Application Instruction:

Submit C.V., letter of interest, and references in your application submission to:

Contact Name: Tiara Williamson

Contact Email: WilliT11@mskcc.org

Pay Range: $72,000 to $113,900

Learn more about working as a Post-Doctoral at MSK: Discover MSK's worldclass core facilities, multidisciplinary mentorship, and robust careerdevelopment programs at https://www.mskcc.org/postdoctoral. As a fellow, you'll leverage cuttingedge technologies-ranging from singlecell and spatialomics platforms to premier animal and organoid cores-while collaborating across oncology, immunology, and computational biology. This uniquely collaborative ecosystem accelerates transformative science into therapies that improve patient outcomes worldwide.

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